11:20-11:40 AM EDTHealthy Metabolism, Healthy AgingMeng Wang, Baylor College of Medicine/HHMI2016 Pioneer AwardNational Institute of Diabetes and Digestive and Kidney Diseases11:40 AM-12:00 PM EDTRethinking EpigeneticsKeith Maggert, University of Arizona2016 Transformative Research AwardNational Institute of General Medical Sciences12:00-12:20 PM EDTPhage-Based Nanomaterials for Antibacterial TherapyIrene Chen, University of California, Los Angeles2016 New Innovator AwardNational Institute of General Medical Sciences

12:35-12:55 PM EDTBioinspired Synthetic Nanobiomaterials for Cardiovascular ImmunotherapyEvan Scott, Northwestern University2015 New Innovator AwardNational Heart, Lung, and Blood Institute12:55-1:15 PM EDTExploration of Biological Diversity to Discover Novel Molecular TechnologiesFeng Zhang, Broad Institute, Inc.2015 Transformative Research AwardNational Institute of Mental Health1:15-1:35 PM EDTBiological Rhythms in Human Health and Infectious DiseaseMicaela Martinez, Columbia University2016 Early Independence AwardNational Institute of Dental and Craniofacial Research, National Institute of Allergy and Infectious Diseases

Poster Session A1:35-2:05 PM EDTPredictive Analytics for Glaucoma Using Data from the All of Us Research Program Sally Baxter, University of California, San Diego 2020 Early Independence AwardChromatin Architecture in Addiction Circuitry Elucidates Biological Mechanisms Underlying Cigarette Smoking and Alcohol Use Traits Hyejung Won, University of North Carolina at Chapel Hill  2019 New Innovator AwardRole of Innate Immune Dysregulation in the Etiology of Dementia Annelise Barron, Stanford University 2020 Pioneer AwardA Novel Quality Control Mechanism for Muscle Stem Cells During Aging Prashant Mishra, The University of Texas Southwestern Medical Center  2017 New Innovator AwardUnexpected Role for Olfactory Receptors in Neurodegeneration Paul Greer, University of Massachusetts Medical School 2019 New Innovator AwardMetabolic Symbiosis Between Regulatory T Cells and the Tumor Microenvironment  Greg Delgoffe, University of Pittsburgh 2017 New Innovator AwardAn evolutionary TORtoise: Conservation and Innovation in Plant TARGET OF RAPAMYCIN SignalingJacob Brunkard, University of Wisconsin - Madison 2016 Early Independence AwardSystemic Dysfunction and Plasticity of the Immune Macroenvironment in Cancer Matthew Spitzer, University of California, San Francisco 2016 Early Independence AwardPoster Session B2:05-2:35 PM EDTOn-Chip Adhesion Frequency Assay  Yuebing Zheng, University of Texas at Austin 2017 New Innovator AwardCommunication Between Networks: Context, Inhibition, and Neuromodulation Caroline Runyan, University of Pittsburgh 2019 New Innovator AwardRefinement of Corticospinal Neuron Activity During Skilled Motor Acquisition Edmund Hollis, Burke Neurological Institute   2017 New Innovator AwardA Novel Oscillator in the Brainstem Synchronizes Neonatal Crying with BreathingKevin Yackle, University of California, San Francisco 2016 Early Independence AwardThe Structural Basis for Protein Energy Landscapes in a De Novo Designed Proteome  Gabriel Rocklin, Northwestern University  2020 New Innovator AwardSynergistic Effector / Environment Decoding in Primate Motor Cortex Carlos Varrgas-Irwin, Brown University 2018 New Innovator AwardDiscovering Peptidic Natural Products by Integrating Genome Mining and Computational Mass Spectrometry Hosein Mohimani, Carnegie Mellon University 2019 New Innovator AwardDecoding RNA Dynamics in Single Cells with Time-resolved Metabolic RNA Sequencing Hao Wu, University of Pennsylvania Perelman School of Medicine2017 New Innovator AwardPoster Session C2:35-3:05 PM EDTIdentifying the Common Pathways Implicated by Common Variation Association Studies for Vascular Disease  Rajat Gupta, Brigham and Women's Hospital  2019 New Innovator AwardMechanisms of Ultrafast Endocytosis Shigeki Watanabe, Johns Hopkins University 2018 New Innovator AwardDevelopmental Retrotransposon Activation Primes Host Immunity for Future Viral-Clearance Zhao Zhang, Duke University 2015 Early Independence AwardSingle-Cell Metabolic Imaging Reveals a RhoA-Triggered A SLC2A3-Dependent Glycolytic Burst in Motile Endothelial Cells Jun Huang, The University of Chicago 2018 New Innovator AwardSwab-Seq: Development of a High-Throughput Platform for Massively Scaled Up SARS-Cov-2 Testing and SequencingValerie Arboleda, David Geffen School of Medicine, UCLA  2017 Early Independence AwardPotentiated JAK-STAT Signaling Upregulates APOL1 Expression in Patient-Derived iPSC-Podocytes Opeyemi Olabisi, Duke University  2019 New Innovator AwardMulti-Scale Spectroscopic Photoacoustic Image Instrumentation for Prostate Cancer Detection  Haichong Zhang, Worcester Polytechnic Institute  2019 Early Independence AwardInfralimbic to Nucleus Accumbens Projections Limit Opioid Addiction  Jasper Heinsbroek, University of Colorado School of Medicine 2019 Early Independence AwardPoster Session D2:35-3:05 PM EDTIn Vivo Single Molecule Analysis of DNA Damage Response Jens Schmidt, Michigan State University 2020 New Innovator AwardCompartmentalized Regulation of Intracellular NAD+  Lulu Cambronne, University of Texas at Austin  2017 New Innovator AwardSpecialized Mechanosensory Epithelial Cells in Gut Intrinsic Tactile Sensitivity  Arthur Beyder, Mayo Clinic   2019 New Innovator AwardMining Bacterial Genomes for Synergistic Antibiotics  Bo Li, University of North Carolina at Chapel Hill  2017 New Innovator AwardSingle Cell Sequencing During Cortical Remodeling Reveals a Conserved Type I Interferon-Responsive Microglial Subset with Enhanced Phagocytic Capacity Anna Molofsky, University of California San Francisco   2017 New Innovator AwardElucidating the Molecular and Circuit Consequences of EBF3 Haploinsufficiency in Neuropsychiatric and Developmental Disorders Hsiao-Tuan Chao, Baylor College of Medicine 2018 Early Independence AwardNext Generation Expansion Microscopy Towards Building Whole Tissue Spatial Molecular Atlas Yongxin Zhao, Carnegie Mellon University  2018 New Innovator Award

3:35-3:55 PM EDTNatural Display of Nuclear-Encoded RNA on the Cell Surface and Its Impact on Cell InteractionSheng Zhong, University of California San Diego2015 Pioneer AwardEunice Kennedy Shriver National Institute of Child Health & Human Development3:55-4:15 PM EDTSpinal Cord Neural Interface for Neuroprosthetics in a Primate ModelAbhishek Prasad, University of Miami2015 New Innovator AwardNational Institute of Biomedical Imaging and Bioengineering4:15-4:35 PM EDTHarnessing Mindset in 21st Century HealthcareAlia Crum, Stanford University2016 New Innovator AwardNational Center for Complementary and Integrative Health

4:50-5:10 PM EDTNeuromodulation of Germline and Implications for Trans-Generational EffectsGiovanni Bosco, Dartmouth College2015 Pioneer AwardNational Institute of Mental Health5:10-5:30 PM EDTGenome Folding, Unfolding, and Refolding in Neurological DiseaseJennifer Cremins, University of Pennsylvania2015 New Innovator AwardNational Institute of Mental Health

11:20-11:40 AM EDTNext-Generation Platforms for Antibody Discovery and EngineeringBrandon Dekosky, University of Kansas Lawrence2016 Early Independence AwardNational Institute of Dental and Craniofacial Research, National Institute of Allergy and Infectious Diseases11:40 AM-12:00 PM EDTFrugal Science: Democratize Science, Diagnostics and Disease SurveillanceManu Prakash, Stanford University2015 New Innovator AwardNational Institute of Allergy and Infectious Diseases12:00-12:20 PM EDTDeconstructing and Reconstructing Human TissuesKelly Stevens, University of Washington2016 New Innovator AwardNational Heart, Lung, and Blood Institute

12:35-12:55 PM EDTPersonalizing Neuromodulation for Executive Functions: Promise in Brain Networks and SocietyJohn Medaglia, Drexel University2015 Early Independence AwardNational Institute of Dental and Craniofacial Research, National Institute of Mental Health12:55-1:15 PM EDTImaging Cell Lineage with a Synthetic Digital Recording SystemMichael Elowitz, Long Cai, and Carlos Lois, California Institute of Technology2017 Transformative Research AwardNational Institute of Mental Health1:15-1:35 PM EDTTranscriptome Analysis of Adult Caenorhabditis elegans Cells Reveals Tissue-Specific Gene and Isoform Expression/ Horizontal and Vertical Transmission of Transgenerational Memories Via the Cer1 TransposonColeen Murphy, Princeton University2015 Pioneer AwardNational Institute of General Medical Sciences

Poster Session E1:35-2:05 PM EDTMolecularly Engineered Model Systems for Studying the Initiation and Progression of Fibrosis  April Kloxin, University of Delaware  2019 New Innovator AwardDe Novo Gene Birth Anne-Ruxandra Carvunis, University of Pittsburgh 2018 New Innovator AwardYellow Fever is a Consumptive Coagulopathy  Adam Bailey, University of Wisconsin-Madison 2020 Early Independence AwardDecoding the Function and Regulation of the Mammalian 12h-Clock Bokai Zhu, University of Pittsburgh 2020 New Innovator AwardAn Acoustofluidic Avidity Cytometer for Detecting Clinical Multiple Sclerosis Feng Guo, Indiana University Bloomington 2020 New Innovator AwardSingle-Molecule Chromatin Fiber Sequencing Exposes Cell and Haplotype-Specific Chromatin Architectures Andrew Stergachis, University of Washington 2020 Early Independence AwardPoster Session F2:05-2:35 PM EDTDiscovering Axonal Regeneration Genes in the Philippine Mouse M. castaneus  Rachel Brem, University of Minnesota Stem Cell Institute 2019 Transformative Research AwardMicrofluidic Lightsheet Microscopy Wesley Legant, UNC - Chapel Hill / UNC - NCSU Joint Department of Biomedical Engineering 2019 New Innovator AwardMitochondrial Origin of Cytosolic Protein Aggregation and Proteostasis Chuankai Zhou, Buck Institute for Research on Aging 2017 Early Independence AwardTopological Data Analysis Reveals a Unique Hub-Like Transition State at Rest in Highly Sampled Individuals Manish Saggar, Stanford University 2018 New Innovator AwardHighly Multiplexed Fluorescence Microscopy Enabled by Ultrabright Pdot Probes for Interrogation of Complex Tissues Joshua Vaughan, University of Washington 2017 Transformative Research AwardPhosphorothioate Epigenetics in the Human Gut Microbiome  Peter Dedon, Massachusetts Institute of Technology 2019 Transformative Research AwardTowards Whole-Brain Electrophysiological Readouts of the Mammalian Nervous System: Injectable Electromagnetic Probes for MRI Aviad Hai, University of Wisconsin-Madison / Department of Biomedical Engineering 2020 New Innovator AwardSelective Control of Protein Synthesis by DDX3 Stephen Floor, UCSF 2018 New Innovator AwardPoster Session G2:35-3:05 PM EDTSingle-Session Interventions for Adolescent Depression in the Context of COVID-19: A Nationwide Randomized-Controlled Trial Jessica Schleider, SUNY Stony Brook University 2019 Early Independence AwardPresynaptic Maturation Determines Activity-Dependent Eye-Specific Competition  Colenso Speer, University of Maryland 2020 New Innovator AwardToward Imaging Bacterial Infection in Humans Mark Sellmyer, University of Pennsylvania 2018 Early Independence AwardProbing Protein Interactions Through Spectral and Diffusional Super-Resolution Microscopy Ke Xu, University of California, Berkeley 2018 New Innovator AwardMethods for Correcting Inference Based on Outcomes Predicted by Machine Learning Tyler McCormick, University of Washington 2019 New Innovator AwardMdrop-Seq: High Throughput Droplet Single-Cell RNA-Seq of Different Fungal Species Reveal Transcriptomic Differences at Single Cell Level in Homogenous Populations Anindita Basu, The University of Chicago 2020 New Innovator AwardThe Subcortical Connectome of the Human Default Mode Network Brian Edlow, Massachusetts General Hospital 2019 New Innovator AwardNative Mass Spectrometry of Potassium Channels in Complex with Phospholipids Arthur Laganowsky, Texas A&M University 2015 New Innovator AwardPoster Session H3:05-3:35 PM EDTStress-Induced RNA-Chromatin Interactions Promote Endothelial Dysfunction  Sheng Zhong, University of California San Diego 2015 Pioneer AwardNovel Cryo-EM Methods and Applications for Macromolecular Structural Biology  Dmitry Lyumkis, The Salk Institute for Biological Studies 2015 Early Independence AwardBidirectional Communication Between Nucleus and Mitochondria Drives Cancer Progression Subhamoy Dasgupta, Roswell Park Comprehensive Cancer Center 2020 New Innovator AwardCell-to-Cell Transfer of Mitochondria from Adipocytes to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity Jonathan Brestoff, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA 2019 Early Independence AwardHigh Speed Multi-Channel Imaging of Neural Activity Yiyang Gong, Duke University 2018 New Innovator AwardHealth Consequences of Shale Gas Development Elaine Hill, University of Rochester  2015 Early Independence Award

3:35-3:55 PM EDTCirculating Tumor Cells Inform Mechanisms of Breast Cancer MetastasisMin Yu, University of Southern California2015 New Innovator AwardNational Cancer Institute3:55-4:15 PM EDTEpidemiological Epididymosomal Epigenomics: The Role of the Male Reproductive Tract in Control of the Sperm EpigenomeOliver Rando, University of Massachusetts Medical School2014 Pioneer AwardNational Institute of Environmental Health Sciences4:15-4:35 PM EDTDeveloping Skin Cancer Education Materials for Darker Skin Populations: Crowdsourced Design, Message Targeting, and Acral Lentiginous MelanomaJakob Jensen, University of Utah2015 New Innovator AwardNational Institute of Biomedical Imaging and Bioengineering

4:50-5:10 PM EDTImplantable Cardiac Energy Harvesting Devices Using Geometrically Structured Piezoelectric Thin FilmsJohn Zhang, Dartmouth College2016 Transformative Research AwardNational Heart, Lung, and Blood Institute5:10-5:30 PM EDTOpening Windows into the Cell: Bringing Structure to Cell Biology using Cryo-Electron TomographyElizabeth Villa, University of California San Diego2016 New Innovator AwardNational Institute of General Medical Sciences

11:00-11:20 AM EDTTranscriptional Control of Brain Excitation in Neurodevelopmental DisordersBruce Yankner and George Church, Harvard Medical School2016 Transformative Research AwardNational Institute of Mental Health11:20-11:40 AM EDTStructural Interiors of Lipid Nanoparticles Regulate RNA Delivery to CellsCecilia Leal, University of Illinois at Urbana Champaign2016 New Innovator AwardNational Institute of Biomedical Imaging and Bioengineering11:40 AM-12:00 PM EDTMarket Area Trends in Menthol and Non-Menthol Cigarette Sales in the United States and Associations with Residential SegregationDaniel Giovenco, Columbia University2016 Early Independence AwardNational Institute of Dental and Craniofacial Research, National Cancer Institute12:00-12:20 PM EDTHow to Make Microtubules and Build the CytoskeletonSabine Petry, Princeton University2016 New Innovator AwardNational Institute of General Medical Sciences

12:35-12:55 PM EDTActive Genetics Comes AliveEthan Bier, Stephen Hedrick, and Andanda Goldrath, University of California, San Diego2016 Transformative Research AwardNational Institute of Allergy and Infectious Diseases12:55-1:15 PM EDTPhasic Activity in Serotonin Neurons and Emotional ReactivityMelissa Warden, Cornell University2015 New Innovator AwardNational Institute of Mental Health1:15-1:35 PM EDTImmunotherapy Directed Against Skin Cancer Precursors Prevents Skin CancerShawn Demehri, Massachusetts General Hospital2015 Early Independence AwardNational Institute of Dental and Craniofacial Research, National Cancer Institute

Poster Session I1:35-2:05 PM EDTSignal Dissemination in the Airway Immune Response Alex Shalek, MIT 2015 New Innovator AwardModel for Postnatal Interneuron Migration in the Gyrencephalic Brain Mercedes Paredes, UCSF 2020 New Innovator AwardLive-Cell Transcriptomics Via Virus-Like Particles Paul Blainey, The Broad Institute  2017 New Innovator AwardSpatiotemporal Dynamics of PIEZO1 Localization Controls Keratinocyte Migration During Wound Healing  Medha Pathak, UC Irvine 2018 New Innovator AwardReorganization of Cortical Activity Patterns Supports Learning of Tactile Shape Discrimination Andrew Hires, University of Southern California 2017 New Innovator AwardObservation of Extracellular and Intracellular Conformational Coupling in Membrane Proteins Using Single-Molecule FRET and Nanodiscs  Gabriela Schlau-Cohen, MIT  2017 New Innovator AwardHighly Multiplexed Spatial Mapping of Microbial Communities Iwijn De Vlaminck, Cornell University 2017 New Innovator AwardCombining Population Genomics, Single-Cell Sequencing, and Electrophysiology to Uncover the Genetic Basis of Cognitive Evolution Michael Sheehan, Cornell University  2017 New Innovator AwardPoster Session J2:05-2:35 PM EDTEnhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High Grade Serous Ovarian Cancer  Sarah Hill, Dana-Farber Cancer Institute 2020 Early Independence Award3D Organoids Generated from Human Trophoblast Stem Cells Model Early Placental Development and Susceptibility to Emerging Viral Infections Thorold Theunissen, Washington University School of Medicine  2019 New Innovator AwardTargeted DNA Integration Without Double-Strand Breaks Using CRISPR RNA-Guided Transposases Samuel Sternberg, Columbia University Irving Medical Center 2020 New Innovator AwardSingle-Cell RNA Sequencing Reveals Cell States and Transcriptional Signatures of Immune and Epithelial Dysregulation that Define Colitis Associated with Immune Checkpoint Inhibitors Alexandra-Chloe Villani, Massachusetts General Hospital/Harvard Medical School 2019 New Innovator AwardBuilding a Sentient Implantable Neurodevice: Early Progress Brian Litt, University of Pennsylvania 2020 Pioneer AwardHigh-Resolution Chemical Imaging of Cells and Tissues Lu Wei, California Institute of Technology 2020 New Innovator AwardTargeting Myc/Max with Hyperstable Synthetic Transcriptional Repressors  Raymond Moellering, The University of Chicago 2017 New Innovator AwardUncovering the Molecular Landscape of Clonal Hematopoiesis Using Cell Reprogramming Sergei Doulatov, University of Washington 2018 New Innovator AwardPoster Session K2:35-3:05 PM EDTWiring Logic of the Early Rodent Olfactory System Revealed by High-Throughput Sequencing of Single Neuron Projections Dinu Albeanu, Cold Spring Harbor Laboratory  2018 Transformative Research AwardDissecting Myeloid-Dependent Signaling Dynamics in the Tumor Microenvironment  Miles Miller, Massachusetts General Hospital 2020 New Innovator AwardStructural Parasitology of the Malaria Parasite Plasmodium falciparum Chi-Min Ho, Columbia University Irving Medical Center 2020 Early Independence AwardEngineering Glycan Interactions at the Cell Surface to Control Signaling and Differentiation Kamil Godula, University of California, San Diego 2015 New Innovator AwardAssessing the Functional Representation of Vocal Musculature in the Motor Cortex of Mice  Cesar Vargas, The Rockefeller University 2019 Transformative Research AwardInhibition of Acetate Metabolism Enhances Host Anti-Tumor Immunity  Zachary Schug, Wistar Institute  2019 New Innovator AwardThe Origins of Vocal Learning Circuits During Development Erich Jarvis, The Rockefeller University  2020 Transformative Research AwardMyocardial Infarction Alters Cardiac Nociception in the Inferior Vagal Ganglia: Implications for Parasympathetic Dysfunction in Heart Disease Marmar Vaseghi, University of California, Los Angeles 2015 New Innovator AwardPoster Session L3:05-3:35 PM EDTIdentifying the Entire Mammalian Micro-Proteome David Sinclair, Harvard Medical School  2017 Pioneer AwardHigh-Throughput Gnotobiotics: Dissecting the Genetics and Genomics of Microbiome Form and Function In C. elegans Buck Samuel, Baylor College of Medicine 2017 New Innovator AwardINSITE: Implantable Nanophotonic Sensors for the Immune Tumor microEnvironment Mekhail Anwar, UC San Francisco  2020 New Innovator AwardBed Bugs: An Emerging Threat to Public Health?  Zachary DeVries, University of Kentucky 2019 Early Independence AwardDeformable Electronic Materials for Two-Way Communication with Biological Systems Darren Lipomi, UC San Diego 2015 New Innovator AwardSynthetic and Systems Biology of Semi-synthetic Cells with Expanded DNA Alphabets  Steven Benner, Foundation for Applied Molecular Evolution 2018 Transformative Research AwardNon-Refoldability is Pervasive Across the E. coli Proteome  Stephen Fried, Johns Hopkins University 2020 New Innovator AwardWriting and Erasing Epigenetic Memories Luke Gilbert, UCSF 2018 New Innovator Award

3:35-3:55 PM EDTSynthetic Biomarkers: A 21st Century Path to Early Cancer Detection Gabriel Kwong, Georgia Institute of Technology2016 New Innovator AwardEunice Kennedy Shriver National Institute of Child Health & Human Development3:55-4:15 PM EDTSystemic Regulation of Brain AgingTony Wyss-Coray, Palo Alto Veterans Institute for Research2015 Pioneer AwardNational Institute on Aging4:15-4:35 PM EDTSystemic Injury Responses in AxolotlJessica Whited, Harvard University2015 New Innovator AwardEunice Kennedy Shriver National Institute of Child Health & Human Development

4:50-5:10 PM EDTRegulation of Protein Function by 3'UTRsChristine Mayr, Memorial Sloan Kettering Cancer Center2016 Pioneer AwardNational Institute of General Medical Sciences5:10-5:30 PM EDTDiscovery of a New Cue Used by Mosquito Disease Vectors to Find PeopleCraig Montell, University of California, Santa Barbara2015 Pioneer AwardNational Institute of Allergy and Infectious Diseases